This slide presentation outlines a study on mammalian cell toxicity of emerging drinking water disinfection byproducts (DBP). Objectives of the study include: U.S. Environmental Protection Agency (USEPA) provides ~50 mg samples of synthesized,
analytical grade DBP;
analyze the direct-acting cytotoxicity and genomic
genotoxicity of the individual DBPs with Chinese
hamster ovary (CHO) cells;
determine the cytotoxic and genotoxic rank order of
the DBPs; and,
develop a quantitative and comparative DBP toxicity
database. Topics outlined include: Impediments to the Development of a Quantitative
and Comparative DBP Toxicity Database; after 32 years, DBPs are still considered
emerging contaminants; Solutions to the Impediments for a
Comparative Toxicology of DBPs; USEPA study titled, "The Occurrence of Disinfection Byproducts (DBPs) of Health Concern in Drinking Water: Results of a Nationwide DBP Study Occurrence Study"; USEPA Stage 2 DBP Rule; alternatives to chlorine disinfection; Emerging DBP Chemical Classes
That Are Currently Being Analyzed; Chinese Hamster Ovary Cells; Mammalian Cell Chronic
Cytotoxicity Assay; Cytotoxicity Absorbancy Data:
Dibromoacetamide; CHO Cell Cytotoxicity
of Haloacetic Acids,
Emerging Haloacid DBPs, Halonitromethanes; Summary of DBPs Analyzed with
the CHO Chronic Cytotoxicity Assay; Genomic DNA Damage Induced by Drinking
Water Disinfection Byproducts; SCGE Analysis of
Haloacetic Acids, emerging Haloacids,
Halonitromethanes in CHO Cells; and, Comparative DBP Genotoxicity Database. Includes figures.
| Edition : | Vol. - No. |
| File Size : | 1
file
, 1.2 MB |
| Note : | This product is unavailable in Ukraine, Russia, Belarus |
| Number of Pages : | 44 |
| Published : | 06/01/2006 |
