The infectivity of Giardia isolates in Mongolian gerbils and in SCID mice
inoculated with a new established G. intestinalis strains of human origin (ISO/90/1,
ISO/90/2) and a reference isolate ATCC 30888 has been investigated.
Inoculation of Mongolian gerbils with trophozoites resulted in an acute and
reproducible pattern of infection. 36 % of inoculated gerbils showed symptoms of
infection after a first inoculation, whereas a second inoculation resulted in infection of
85% of the same gerbils. The group of SCID mice infected with ISO/90/2 failing to
release cysts in the faecal material, while the second inoculated group infected with
ISO/90/1 showed a low number of cysts at 13 days post inoculation. Cyst excretion was
intermittent mostly released during the second and the third week of infection.
Mongolian gerbils are useful to assess viability and infectivity of parasites from
various sources. Strain differences may contribute to the development of different patterns
of infections, which rely to clinical consequences in the diagnosis.
Includes tables, figures.
| Edition : | Vol. - No. |
| File Size : | 1
file
, 220 KB |
| Note : | This product is unavailable in Ukraine, Russia, Belarus |
| Number of Pages : | 25 |
| Published : | 09/22/2002 |
