Atmospheric pressure ionization (API) LC/MS and LC/MS/MS technology has had a
wide range of applications in environmental analysis. These include the identification,
confirmation, and quantification of polar disinfection byproducts (DBPs), pesticides, herbicides
and other contaminants in water samples. The improved LC/MS and LC/MS/MS
techniques have made it possible to directly analyze aqueous samples with a sensitivity of subpart
per billion to low part per billion levels for many organic chemicals. Direct aqueous
analysis has four obvious advantages. These include: significantly reduced analytical costs
associated with sample collection, shipping, storage, and extraction; improved accuracy and
precision of analytical results; improved turn-around time of analytical results; and,
reduction of matrix effects because the samples are not preconcentrated.
This paper summarizes several applications of LC/MS and LC/MS/MS technology for
direct aqueous analysis of polar regulated and unregulated contaminants in finished drinking
water and source water. The contaminants studied include perchlorate, ethylenethiourea
(ETU), 2,6-dichlorobenzamide (BAM), and a number of selected pesticides. The method
detection limits (MDLs) were calculated as a product of the standard deviation of seven replicate
analyses and the student's t value with a 99% confidence level and n-1 degrees of freedom.
The method accuracy (mean recovery) and precision (relative standard deviation, RSD) were
determined by measuring 4-7 replicate laboratory fortified blanks (LFBs). The two analytical
systems used were a Waters 2690 LC equipped with a ZMD detector and a Waters 2695 LC
equipped with a Quattro micro API detector (Waters, Milford, MA). Includes 12 references, tables.
| Edition : | Vol. - No. |
| File Size : | 1
file |
| Note : | This product is unavailable in Ukraine, Russia, Belarus |
| Number of Pages : | 5 |
| Published : | 11/15/2004 |
