Recently, the U.S. Environmental Protection Agency (USEPA) published Method 1694 as a
performance-based screening method using LC/ESI/MS/MS combined with an SPE technique,
which is applicable for analysis of seventy-four pharmaceuticals/personal care products (PPCPs) in water, soil, sediment, and biosolids
through two extractions and four analyses. In Method 1694, isotope dilution calibration is used
for the analytes that have isotopically labeled analogs. Internal standard calibration using
isotopically labeled compounds is used for those analytes that do not have isotopically labeled
analogs. However, as a result of several issues with the current version of Method 1694, extensive validation and improvement
must be performed to provide a more accurate and less costly method to meet the analytical
need.
This paper presents the results of validating Method 1694. Efforts include:
improving the method sensitivity, accuracy, and precision through a series of modifications;
studying more PPCPs that have been detected in the environment; developing two separate
extraction and analysis methods instead of four methods to reduce costs; and, investigating the
stability and holding time requirement of selected PPCPs. Includes abstract only.
| Edition : | Vol. - No. |
| File Size : | 1
file
, 720 KB |
| Note : | This product is unavailable in Ukraine, Russia, Belarus |
| Number of Pages : | 1 |
| Published : | 11/01/2009 |
