Clinical and Laboratory Standards Institute document I/LA31-A--Newborn Screening for Preterm, Low Birth Weight, and Sick
Newborns; Approved Guideline addresses newborn screening of preterm, low birth weight (LBW), and sick newborns worldwide
to detect treatable conditions before physical damage can occur to the infant. In developed countries, advances in the treatment
they receive have improved survival rates, making the early detection of conditions detected by newborn screening even more
important. The physiological states associated with preterm, LBW, and sick newborns, and the treatments they receive, directly
affect the reliability of results for many conditions screened in public health dried blood spot and newborn hearing screening
systems. This guideline describes the effects of maternal and infant conditions, as well as treatments given to newborns. It also
provides the rationale for the recommended intervals for screening designed to minimize the risk of missing or delaying a
diagnosis in an affected newborn. It is intended for use by those involved in any aspect of newborn screening specimen collection
or hearing screening testing and follow-up, including health care providers, parents, public health professionals, and others
concerned with the health and welfare of newborns.
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