Antimicrobial Pharmacodynamics in Theory and Clinical Practice PDF

Preface

The second edition of this book assumes that to use antibiotics properly, the clinician needs to understand fundamental concepts of pharmacodynamics. While many infectious disease physicians do understand these concepts, they are not the only physician group prescribing antibiotics. The objective of the second edition is to review the scientific and medical literature concerning antibiotics and pharmacodynamics, and then synthesize this information into an easy to understand discussion of the concepts and theory, along with application of these theories and concepts.

This book includes a discussion of the pharmacodynamics of all of the major classes of drugs. These include penicillins, cephalosporins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, azalides, ketolides, glycopeptides, metronidazole, clindamycin, tetracyclines, and antifungals. In addition to the topics on the antibiotics listed above, the second edition has added chapters on malaria, some antivirals, a section on non-clinical models of infection, a chapter on streptogramins and oxazolididones, and a section on pharmacodynamics in drug development. In addition to an updated introductary chapter, we include a chapter on the impact of pharmacodynamics on breakpoint selection for susceptibility testing, while retaining and updating the chapter on resistance and pharmacoeconomics.

This book is unique in that no other text of its kind currently exists and our chapter authors are among the leaders in the field. This book will find an audience in a large array of healthcare disciplines including college educators; medical, pharmacy, and microbiology students; infectious disease physicians; pharmacy specialists; medical house staff; clinical and staff pharmacists; clinical microbiologists; and other healthcare decision makers.