Biomimetic Microengineering PDF

This book will examine the relevant biological subjects involved in biomimetic microengineering as well as the design and implementation methods of such engineered microdevices. Physiological topics covered include regeneration of complex responses of our body on a cellular, tissue, organ, and inter-organ level. Technological concepts in cell and tissue engineering, stem cell biology, microbiology, biomechanics, materials science, micro- and nanotechnology, and synthetic biology are highlighted to increase understanding of the transdisciplinary methods used to create the more complex, robust biomimetic engineered models. The effectiveness of the new bioinspired microphysiological systems as replacements for existing in vitro or in vivo models is explained through sections that include the protocols to reconstitute three-dimensional (3D) structures, recapitulate physiological functions, and emulate the pathophysiology of human diseases. This book will also discuss how researchers can discover bridge technologies for disease modeling and personalized precision medicine.

Features

•Focuses on cutting edge technologies that enable manipulation of living systems in a spatiotemporal manner.

•Incorporates research on reverse engineering of comples microenvironmental factors in human diseases.

•Highlights technologies related to patient-specific personalized medicine and their potential uses.

•Written by chapter authors who are highly respected researchers in science and engineering.

•Includes extensive references at the end of each chapter to enhance further study.

Hyun Jung Kim is an Assistant Professor in the Department of Biomedical Engineering at The University of Texas at Austin. After receiving hois Ph.D. degree at Yonsei University in the Republic of Korea, he did extensive postdctoral research at both the University of Chicago and the Wyss Institute at Harvard University. These efforts resulted in cutting-edge breakthroughs in synthetic microbial community research and organomimetic human Gut-on-a-Chip microsystem. His research on Gut-on-a-Chip technology leads to the creation of a microfluidic device that mimics the physiology and pathology of the living human intestine. Since 2015, he has explored novel human host-microbiome ecosystems to discover the disease mechanism and new therapeutics in inflammatory bowel disease and colorectal cancers at UT Austin. In collaboration with clinicians, his lab is currently developing disease-oriented, patient-specific models for the advancement in pharmaceutical and clinical fields.

• Focuses on cutting edge technologies that enable manipulation of living

systems in a spatiotemporal manner.

• Incorporates research on reverse engineering of complex

microenvironmental factors in human diseases.

• Highlights technologies related to patient-specific personalized medicine

and their potential uses.

• Written by chapter authors who are highly respected researchers in

science and engineering.

• Includes extensive references at the end of each chapter to enhance

further study.

Hyun Jung Kim is an Assistant Professor in the Department of Biomedical

Engineering at The University of Texas at Austin. After receiving his Ph.D. degree at

Yonsei University in the Republic of Korea, he did extensive postdoctoral research

at both the University of Chicago and the Wyss Institute at Harvard University. These

efforts resulted in cutting-edge breakthroughs in synthetic microbial community

research and organomimetic human Gut-on-a-Chip microsystem. His research

on Gut-on-a-Chip technology leads to the creation of a microfluidic device that

mimics the physiology and pathology of the living human intestine. Since 2015,

he has explored novel human host-microbiome ecosystems to discover the disease

mechanism and new therapeutics in inflammatory bowel disease and colorectal

cancer at UT Austin. In collaboration with clinicians, his lab is currently developing

disease-oriented, patient-specific models for the advancement in pharmaceutical

and clinical fields.

Author: Hyun Jung Kim