Bone Tissue Engineering PDF

Preface

This book has been designed to emphasize the fundamentals of bone tissue engineering. The editors have identified key topics, thought-leaders, researchers, and clinicians who understand basic elements of bone and the translation of that knowledge to exciting applications for patients.

The book is organized into four sections. The first section edited by Bruce Doll, DDS, PhD contains three chapters with up-to-date information on the development of the skeletal system, cell lineage and progression, extracellular molecules, and the physiology of bone dynamics.

The second section includes four chapters and is edited by Charles Sfeir, DDS, PhD. In two chapters, there is an emphasis on the basic elements of bone, including signaling molecules and pathways, and the regulatory interactions among molecules and pathways, as well as an in-depth, contemporary explanation of the organic and inorganic substrata. The third and fourth chapters in this section build on previous chapters and include scaffold design and development, with two distinguished groups offering different innovative approaches for bone tissue engineering scaffolds.

Section three, coedited by Jeffrey O. Hollinger, DDS, PhD and Thomas Einhorn, MD is the logical sequence from the first two sections. Section three has three chapters that focus on fundamental statistics, animal models, and key outcome techniques in biomechanics and tissue morphology quantitation that will guide the maturation of experimental bone tissue-engineered designs to the clinic. This section will answer important questions: how do I determine how many experimental animals will be necessary to detect statistical significance? What is the best experimental preclinical model for a particular clinical indication?

Thomas Einhorn, MD and Jeffrey O. Hollinger, DDS, PhD are the coeditors of section four, with three chapters discussing opportunities for tissue engineering and bone, as well as thematic opportunities for tissue engineering in the spine, craniofacial, and dental areas.

I want to thank my coeditors and contributors for their highly informative chapters. The comprehensive nature of the chapters with extensive bibliographies will make this book an invaluable resource for students, clinicians, and scientists interested in bone tissue engineering.