Cardiovascular Toxicology PDF

Preface

The first three editions of Cardiovascular Toxicology provide the foundation for the latest, fourth edition of this monograph. The first edition, edited by Ethard Van Stee, was published in 1982, and the next two editions, edited by Daniel Acosta, Jr., were published in 1992 and 2001, respectively. The central theme of this book is to provide an in-depth overview of myocardial and vascular toxicity of chemical agents.

It is one of the few toxicology texts that focus entirely on toxicity of chemicals to the cardiovascular system. In addition, the monograph separates the discussion of the cardiovascular system into the heart and vascular system, which is not commonly found in other texts.

The latest edition continues to focus on mechanistic and molecular aspects of chemical injury to the heart and the vasculature. Furthermore, it comprises several key sections beyond general cardiovascular toxicology, such as a major review on advances in the field, an up-to-date review of ischemic cell injury, and advances in methodology for measuring and evaluating cardiovascular function and toxicity. An attempt has been made to provide pertinent information on key, well-known cardiovascular toxicants. Thus, many of the chapters are categorized as to the cardiovascular toxic effects of major chemical and therapeutic classes of drugs, industrial agents, and pollutants. The authors have revised and updated all of the previous chapters with the latest findings in their respective areas of interest; several of the chapters have new authors, which brings a new perspective to the topic.

We believe that the fourth edition will serve as a useful reference to clinicians, public health officials, industrial and experimental toxicologists, and other interested professionals. This monograph may also serve as a recommended or supplementary text for advanced graduate courses in target organ toxicology and may assist students and health professionals pursuing a career in academia, industry, or government.