CRC DERMATO PDF

Preface

Dermatotoxicology—First edition, published in 1977, covered much of the embryonic fi eld in 567 pages.

The seventh edition (2007)—consisting of 108 chapters— summarizes much of the current fi eld, defi ning what was largely an intuitive science to today's often refi ned metrics and mechanisms.

Most chapters from previous editions have been revised. New chapters refl ect the expanding science. Major areas include pharmacogenetics, racial differences, percutaneous penetration enhancers, sensitive skin, mechanisms of allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD), occupational ACD, mechanisms in cutaneous drug hypersensitivity reactions, OECD guidelines, stratum corneum quantifi cation, Kawai method for testing irritation, tests for sensitive skin, ACD threshold doses, ECVAM, corticosteroidinduced glaucoma, genotoxic activity, exogenous ochronosis, air bag injuries, cigarette and skin, chemical analysis of tattoo, anti-irritant, medical device regulation, diagnosis of drug hypersensitivity, water decontamination, hair in toxicology, textiles and human skin, in vivo human transfer of topical bioactive drug, fragrance allergens, ten genotypes of ICD, reconstituted human epidermis, functional map, and skin buffering.

Society (government, the media, the public, and the law) has become increasingly aware of the skin as an important route of systemic exposure to chemicals—adding impetus to the fi eld of dermatotoxicology.

Unfortunately, in spite of the seventh edition's mass, much science was left out—so that editions one through six remain not relics—but sources of relevant information.

ur special thanks go to Patricia Roberson for the meticulous management of this complex volume. We welcome your critiques and suggestions for the eighth edition.