Ocular Neuroprotection PDF

Preface

Neuroprotection comprises a broad range of therapeutic strategies aimed at preventing death of neurons in trauma or disease. As applied to ocular disorders, neuroprotection has received enormous attention in past years because of its potential for treating diseases that were heretofore untreatable or difficult to treat, including disorders primarily involving death of photoreceptors (such as in macular degeneration, retinitis pigmentosa, and retinal detachment) or retinal ganglion cells (such as in glaucoma).

The goal of this book is to provide the reader with up-to-date ocular neuroprotection research methods that are used in leading laboratories worldwide. Chapters 1 through 15 focus on research methods at the laboratory level, with emphasis on various cell culture and animal models, classes of neuroprotective drugs, biochemical and cellular outcome measures, and applicability to human disease. Chapters 16 through 18 focus on how clinical trials of neuroprotection may be carried out, concentrating on issues of recruitment, outcome measures, and requirements of regulatory agencies.

The information conveyed in this book is intended to be practical. The chapters address the nuts and bolts of the actual methods themselves, along with potential problems, solutions to those problems, potential shortcuts (and contraindications to shortcuts), and specific suppliers, where appropriate.

The book is not intended to be an exhaustive presentation of research data or theories, but rather to provide a focused description of useful methods for conducting neuroprotection research. This book will acquaint those considering research in the area with the major techniques, tools, and issues in ocular neuroprotection, while investigators with experience in neuroprotection research may benefit from exposure to new models, methodologies, and clinical approaches. Regardless of the reader's experience, this volume will be an invaluable resource.

We sincerely thank all the contributors-leading scientists in their fields- who have generously shared their knowledge and expertise in each chapter.