Topical Absorption of Dermatological Products PDF

Preface

This book is based on Bronaugh and Maibach's Percutaneous Absorption: Third Edition and In Vitro Percutaneous Absorption (Marcel Dekker, Inc.). It is a condensed entry into this complex area geared toward dermatologists, pharmacists, toxicologists, cosmetic chemists working in the area of transdermal drug absorption, and others concerned with clinical treatment and studies involving the skin. The chapters are divided into three parts. "Mechanisms of Absorption" contains chapters that discuss the effects of skin metabolism, hair follicles, occlusion, and other factors on skin absorption. Chapters in the "Methodology" part discuss the various issues involved in measuring percutaneous absorption such as in vivo and in vitro methodology, single versus multiple dosing, the relationship of blood flow to absorption, and the significance of drug concentrations in the different layers of skin. In "Drug and Cosmetic Absorption," many updated and new chapters have been added on topical dermatological products.

We would like to thank the authors for preparing outstanding chapters and Sandra Beberman and Barbara Mathieu of Marcel Dekker, Inc., for their expert editorial guidance.