NCRP 186 PDF

Abstract:

The overall aim of this Report is to provide input for the development of biologically based dose-response models for radiation-induced cancers and circulatory disease that use an adverse outcome pathways and key-events approach for providing parameters for these models. These mechanistic data can be integrated with the most recent epidemiologic data to develop overall dose response curves for radiation-induced adverse health outcomes. This integration of the findings from radiation biology and epidemiology will enhance the risk assessment process by reducing uncertainties in estimated risk following exposure to low doses and low dose rates of ionizing radiation.