All chromates (chromium(VI) or hexavalent chromium)
are hazardous materials with great non-cancer human health risks
associated with occupational exposure. Certain chromates are known
human carcinogens when inhaled. There are three important
metabolic reactions involving chromates that can occur in the human
body, absorption, reduction, and precipitation. Only doubly charged
dissolved chromate ions can be absorbed through epithelial cells (skin,
alveoli, erythrocytes, and the small intestine) via non-specific ion
channels. Reduction, the conversion of chromate (CrO4
-2) to the non-
toxic chromium+3 is favored at lower pHs and in the presence of
organic materials such as saliva and mucous and occurs in all organs.
Precipitation may occur in the stomach. Epidemiological and
toxicological results strongly support the theory that chromates do not
cause cancers other than in the lung and lung cancers are associated
with the inhalation of insoluble chromates, which are retained in the
lung.
Includes references, tables.
| Edition : | Vol. - No. |
| File Size : | 1
file
, 220 KB |
| Note : | This product is unavailable in Ukraine, Russia, Belarus |
| Number of Pages : | 21 |
| Published : | 06/16/2002 |
