This powerpoint presentation begins by presenting a brief overview of disinfection byproducts (DBPs) as emerging contaminants. Research objectives are listed and include the following:
obtain samples (~50 mg) of synthesized, analytical
grade DBPs from the U.S. Environmental Protection Agency (USEPA);
analyze the direct-acting cytotoxicity and genomic
genotoxicity of the individual DBPs with Chinese
hamster ovary (CHO) cells;
determine the cytotoxic and genotoxic rank order of
the DBPs; and,
develop a quantitative and comparative DBP toxicity
database. Presentation conclusions indicate the following:
with our current database, ~70 DBPs were
compared on a level toxicological playing field;
we can quantitatively compare the cytotoxicity of
DBPs using their %C1/2 values;
we can quantitatively compare the genotoxicity of
DBPs using the SCGE Genotoxic Potency values;
we can compare classes or specific groups of
DBPs based on their Toxicity Index, within a
class, the reciprocal of the averaged median %C1/2 values is the cytotoxicity index value and the
reciprocal of the averaged median genotoxic
potency values is the genotoxicity index value; the current USEPA-regulated DBP classes
(THMs and HAAs) are substantially less toxic
than emerging DBPs;
iodinated-DBPs are far more toxic than their
brominated and chlorinated analogs;
N-DBPs are much more toxic than C-DBPs;
the occurrence of these emerging DBPs are on
the rise because of changes in source water
quality and the increased use of alternative
water disinfectants; and,
these emerging DBPs may pose adverse health
risks. Includes figures.
| Edition : | Vol. - No. |
| File Size : | 1
file
, 1.2 MB |
| Note : | This product is unavailable in Ukraine, Russia, Belarus |
| Number of Pages : | 30 |
| Published : | 11/01/2008 |
