Epidemiologic data suggest some associations
between disinfection byproduct (DBP) exposure
and human health risk. However, animal toxicology
data show effects only at DBP doses considerably
higher than environmental concentrations. This may be
because human exposure to DBPs is typically at low
levels. The major health risk posed by DBPs is likely to
be caused by multiple, rather than single, exposures.
Thus, DBP health effects and risk assessment cannot be
fully characterized by single-chemical toxicology studies
but are more appropriately addressed by research on
DBP mixtures. This article outlines a structured
approach to health-based research on DBP mixtures.
Assessment guidance would stem from available data in
three areas: the complex mixture of concern, a sufficiently
similar mixture, and data based on components
and interactions. Accurate evaluation of the human
health risks associated with DBP mixtures can be
achieved only through well-planned, structured experiments
that are designed to address specific risk assessment
issues, efficiently use resources, and are coordinated
by a multidisciplinary team of scientists. Valid
health-based information on DBP mixtures provided to
water suppliers will improve assessments of drinking
water quality and help utilities choose among treatment
alternatives. Includes 43 references, figure.
| Edition : | Vol. 95 - No. 6 |
| File Size : | 1
file
, 220 KB |
| Note : | This product is unavailable in Ukraine, Russia, Belarus |
| Number of Pages : | 8 |
| Published : | 06/01/2003 |
