Recent work has shown that polychromatic ultraviolet (UV) sources, such as medium-pressure
(MP) UV, are significantly more effective than low-pressure (LP) UV at inactivating
adenovirus in cell culture infectivity assays (Eischeid et al., 2009; Linden et al.,
2007). It is thought that LP UV primarily damages the viral DNA, and that this
damage may be repaired during cell culture infectivity assays, allowing the virus
to successfully infect cells and escape inactivation. Such host cell reactivation of
the damaged virus does not appear to occur after MP UV irradiation, and this
may be because of more widespread, extragenomic damage to the viral particle
caused by medium pressure UV. Includes 10 references, figures.
| Edition : | Vol. - No. |
| File Size : | 1
file
, 750 KB |
| Note : | This product is unavailable in Ukraine, Russia, Belarus |
| Number of Pages : | 7 |
| Published : | 11/01/2009 |
